![]() ![]() Recurrent herpes labialis (RHL) is one of the most common viral infections worldwide. The available treatments have limited efficacy in preventing the recurrence of ulcerative lesions and reducing the duration of illness. Metaz 0.1 Cream belongs to a group of medicines called topical corticosteroids. The objective of this review was to identify the effectiveness of topical corticosteroids in addition to antiviral therapy in the treatment of RHL infection. MethodsĪ systematic review of randomized clinical trials comparing the efficacy of combined therapy (topical corticosteroids with antiviral) with placebo or antiviral alone in the management of RHL was conducted. ![]() MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane library, and Google Scholar databases were searched. We used RevMan software to conduct the meta-analysis. A fixed-effects model was used for mild to moderate heterogeneity, whereas a random-effects model was used for significant heterogeneity. Heterogeneity among trials was established using I 2 and chi-square test for heterogeneity. Resultsįour studies that fulfilled the selection criteria were included in this review. The total number of participants across included studies was 1,891 (range, 29 to 1,443). Metoz 2.5Mg Tablet is an known as a quinazoline diuretic which has actions that are quite similar to thiazide diuretics. The antiviral drugs used were acyclovir, famciclovir, and valacyclovir. Corticosteroids used were 1% hydrocortisone and 0.05% fluocinonide. Pooled results showed that patients receiving combined therapy had a significantly lower recurrence rate of ulcerative lesions compared to those in both the placebo group (OR, 0.50 95% CI, 0.39-0.66 P < .001) and the antiviral treatment alone group (OR, 0.73, 95% CI, 0.58–0.92 P = .007). The healing time was also significantly shorter in combined therapy in comparison to placebo (P < .001). However, there were no significant differences in healing time between combined therapy and antiviral alone. The adverse reactions in combined therapy were not significantly different than the placebo group (OR, 1.09 95% C, 0.75-1.59 P = .85). Treatment with combined therapy is safe and more effective than placebo or antiviral alone for preventing the recurrence of ulcerative lesions in RHL infection. ![]() When used correctly it is a safe and effective treatment. It works by reducing the actions of chemicals in the body that cause inflammation of the skin. It is effective in treating skin conditions with inflammation and itching such as eczema, psoriasis, and dermatitis. Herpes labialis infection is a global public health problem, with 15 to 40% of the population who experience symptomatic outbreak. Metaz F Cream belongs to a group of medicines called topical corticosteroids. Infection rates are high among HIV positive patients about 95% of patients are seropositive to herpes simplex type I antigen. There are 3 formulations of mometasone furoate with various indications. In developed countries, one third of the population suffer from recurrent herpes labialis. metaz cream is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. ![]()
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